REG4

Across TCGA patient cohorts, REG4 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible REG4-associated genes across cancer lineages are Bak, EGFR_pY1068, and NF2. Each is linked with REG4 in more than 1 cancer types. Because this analysis shows association rather than direction, both REG4-to-partner and partner-to-REG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bak grouped by REG4-low versus REG4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REG4→partner) and Y-score (partner→REG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Bak →	+0.220	+2.182	.030	.033	3	1
UCEC	EGFR_pY1068 →	-0.290	-3.169	.021	.019	3	1
UCEC	NF2 →	+0.313	+2.321	.003	.035	3	1
UCEC	PEA-15_pS116 →	+0.473	+2.321	.007	.035	3	1
UCEC	Rab25 →	-0.511	-3.000	.002	.036	3	1
UCEC	Shc_pY317 →	-0.165	-2.321	.030	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Bak by REG4 expression — SKCM

Explore this box plot interactively →