REG3G

Across TCGA pan-cancer cohorts, REG3G Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated REG3G data layer compared with 17 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher REG3G Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated REG3G expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

UCS, SKCM, and SCLC are the cancer types where REG3G Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Median	All	0.102	0.688	<.001	36	view →
SKCM	DFS	Median	IV	0.036	0.433	<.001	13	view →
SCLC	OS	Median	III,IV	0.055	0.640	<.001	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
ESCA	DFS	Median	All	0.167	0.506	.031	3	view →
LUSC	DFS	Median	All	0.144	0.712	.009	3	view →
LUAD	DFS	Median	All	1.000	0.754	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

REG3G–UCS (OS)

Open the UCS breakdown →