REG1B

Across TCGA pan-cancer cohorts, REG1B Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated REG1B data layer compared with 20 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher REG1B Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated REG1B expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

ESCA, UCEC, and GBM are the cancer types where REG1B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	DFS	Median	II,III,IV	0.023	0.523	<.001	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
GBM	DFS	Median	All	0.048	0.242	.006	3	view →
SKCM	DFS	Median	All	0.893	0.713	.029	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

REG1B–ESCA (DFS)

Open the ESCA breakdown →