REEP5

Across TCGA patient cohorts, REEP5 mutation is significantly associated with the RNA expression of many other genes, with 1,660 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible REEP5-associated genes across cancer lineages are SEPTIN14P19, IGHD4-4, and LINC02622. Each is linked with REEP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both REEP5-to-partner and partner-to-REEP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEPTIN14P19 grouped by REEP5-low versus REEP5-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REEP5→partner) and Y-score (partner→REEP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	SEPTIN14P19 →	+0.038	+4.685	<.001	.007	3	2
UCEC	IGHD4-4 →	+0.477	+2.904	<.001	.009	3	2
SKCM	LINC02622 →	+0.066	+5.680	<.001	.003	3	2
UCEC	IGHV3OR16-8 →	+0.674	+3.272	.002	<.001	3	1
UCEC	MMP28 →	-0.478	-3.438	.004	.005	3	1
UCEC	ARF4P1 →	+0.490	+2.321	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,660 associations by consensus.

SEPTIN14P19 by REEP5 expression — BLCA

Explore this box plot interactively →