REEP4

Across TCGA pan-cancer cohorts, REEP4 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated REEP4 data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher REEP4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated REEP4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and COAD show a favorable association.

PDAC, UCEC, and COAD are the cancer types where REEP4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	II,III,IV	0.219	0.486	<.001	34	view →
UCEC	OS	Tertile	III,IV	1.000	0.345	.013	24	view →
COAD	DFS	Median	All	1.000	0.902	.038	18	view →
CCRCC	OS	Median	III,IV	0.599	0.937	.006	18	view →
LUAD	DFS	Tertile	III,IV	0.982	0.585	.006	12	view →
LSCC	DFS	Quartile	II,III,IV	0.936	0.562	.017	10	view →
HNSC	DFS	Median	All	0.698	1.000	.020	8	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

REEP4–PDAC (DFS)

Open the PDAC breakdown →