REEP4

Across TCGA pan-cancer cohorts, REEP4 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of REEP4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where REEP4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types REEP4 is over-expressed in tumor.

KIRC, KIRP, and HNSC are the cancer types where REEP4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in REEP4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.135	<.001	12	view →
KIRP	All	IV	+2.375	<.001	11	view →
HNSC	All	All	+0.850	<.001	10	view →
LIHC	Female	All	+1.418	<.001	9	view →
KICH	All	II,III,IV	+1.032	<.001	9	view →
UCEC	All	III,IV	+1.996	<.001	8	view →
LUSC	All	III,IV	+1.818	<.001	8	view →
STAD	All	All	+1.253	<.001	8	view →
BLCA	Male	All	+1.525	.005	7	view →
BRCA	All	III,IV	+1.457	<.001	6	view →
CHOL	Female	All	+2.950	<.001	5	view →
PAAD	Male	All	+0.444	.010	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

REEP4–KIRC

Open the KIRC breakdown →