REEP4

Across TCGA patient cohorts, REEP4 protein abundance is significantly associated with the RNA expression of many other genes, with 10,956 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible REEP4-associated genes across cancer lineages are ARHGEF6, ESCO2, and CDCA2. Each is linked with REEP4 in more than 5 cancer types. Because this analysis shows association rather than direction, both REEP4-to-partner and partner-to-REEP4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, REEP4 versus ARHGEF6 in BRCA, with a Pearson correlation of -0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REEP4→partner) and Y-score (partner→REEP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ARHGEF6 →	-0.868	-0.430	<.001	.001	3	6
COAD	ESCO2 →	+0.781	+0.282	<.001	<.001	3	6
LUAD	CDCA2 →	+0.778	+0.227	<.001	<.001	3	6
UCEC	ADGRD1 →	-1.021	-0.288	<.001	.007	3	5
HNSC	PDE1A →	-0.730	-0.391	<.001	<.001	3	5
OV	XPO7 →	+0.688	+0.354	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,956 associations by consensus.

REEP4 vs ARHGEF6 — BRCA

Explore this scatter interactively →