REEP4

Across TCGA patient cohorts, REEP4 mutation is significantly associated with the RNA expression of many other genes, with 505 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible REEP4-associated genes across cancer lineages are MIR138-2, RNU6-484P, and DAOA. Each is linked with REEP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both REEP4-to-partner and partner-to-REEP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR138-2 grouped by REEP4-low versus REEP4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REEP4→partner) and Y-score (partner→REEP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR138-2 →	+0.301	+4.614	<.001	.006	3	2
UCEC	RNU6-484P →	+0.621	+2.166	<.001	.006	3	2
CESC	DAOA →	+0.036	+4.760	<.001	.003	3	2
COAD	LINC01707 →	+0.237	+6.693	<.001	<.001	3	2
COAD	RN7SL564P →	+1.161	+4.925	<.001	<.001	3	2
COAD	RN7SL656P →	+0.210	+5.332	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 505 associations by consensus.

MIR138-2 by REEP4 expression — SKCM

Explore this box plot interactively →