REEP4

Across TCGA patient cohorts, REEP4 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible REEP4-associated genes across cancer lineages are FoxM1, INPP4B, and Notch1. Each is linked with REEP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both REEP4-to-partner and partner-to-REEP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by REEP4-low versus REEP4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REEP4→partner) and Y-score (partner→REEP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.337	+2.817	.012	.036	3	1
UCEC	INPP4B →	-0.369	-3.308	.029	.010	3	1
UCEC	Notch1 →	+0.194	+3.321	.008	.010	3	1
UCEC	PCNA →	+0.456	+3.321	<.001	.010	2	2
UCEC	PDCD4 →	-0.916	-2.990	<.001	.036	2	2
UCEC	AR →	-0.509	-3.321	.009	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

FoxM1 by REEP4 expression — UCEC

Explore this box plot interactively →