REEP4

Across TCGA cell cohorts, REEP4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,616 significant associations in total. BONE shows the largest number of these associations.

The most reproducible REEP4-associated GO terms across cancer lineages are Negative regulation of sister chromatid cohesion, Positive regulation of protein localization to endoplasmic reticulum, and Mitotic nuclear division. Each is linked with REEP4 in more than 12 cancer types. Because this analysis shows association rather than direction, both REEP4-to-partner and partner-to-REEP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of sister chromatid cohesion grouped by REEP4-low versus REEP4-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (REEP4→partner) and Y-score (partner→REEP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Negative regulation of sister chromatid cohesion →	+0.117	+0.867	.002	.002	3	13
SKIN	Positive regulation of protein localization to endoplasmic reticulum →	+0.102	+0.668	.001	<.001	3	12
SKIN	Mitotic nuclear division →	+0.072	+0.661	.001	.002	3	11
BONE	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.150	+0.983	<.001	<.001	3	11
BONE	Signal transduction in response to DNA damage →	+0.092	+1.312	.001	<.001	3	11
BONE	Regulation of DNA-templated DNA replication →	+0.123	+1.059	.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,616 associations by consensus.

Negative regulation of sister chromatid cohesion by REEP4 expression — SOFT_TISSUE

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