REEP3

Across TCGA pan-cancer cohorts, REEP3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated REEP3 data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher REEP3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated REEP3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

LSCC, LUAD, and HNSC are the cancer types where REEP3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	II,III,IV	0.649	0.994	<.001	26	view →
LUAD	DFS	Quartile	II,III,IV	0.189	1.000	.004	23	view →
HNSC	DFS	Tertile	II,III,IV	0.976	0.888	.024	6	view →
GBM	OS	Tertile	All	0.387	0.615	.010	2	view →
CCRCC	OS	Tertile	All	0.902	0.728	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

REEP3–LSCC (OS)

Open the LSCC breakdown →