REEP3

Across TCGA pan-cancer cohorts, REEP3 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of REEP3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where REEP3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types REEP3 is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

HNSC, LUAD, and BRCA are the cancer types where REEP3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in REEP3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.951	<.001	11	view →
LUAD	All	All	+0.386	<.001	6	view →
BRCA	All	II,III,IV	+0.275	.001	6	view →
LIHC	All	All	+0.314	<.001	5	view →
COAD	All	All	−0.455	.007	4	view →
PAAD	All	All	+1.152	.030	2	view →
CHOL	All	All	+0.953	.007	2	view →
READ	All	All	−0.745	.002	2	view →
LUSC	All	All	−0.213	.043	2	view →
ESCA	All	All	+0.736	.044	1	view →
THCA	All	All	+0.247	.028	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

REEP3–HNSC

Open the HNSC breakdown →