REEP3

Across TCGA patient cohorts, REEP3 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible REEP3-associated genes across cancer lineages are eEF2, eIF4E, and INPP4B. Each is linked with REEP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both REEP3-to-partner and partner-to-REEP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by REEP3-low versus REEP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REEP3→partner) and Y-score (partner→REEP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.403	+2.999	.012	.035	3	1
UCEC	eIF4E →	+0.220	+2.700	.020	.006	3	1
UCEC	INPP4B →	-0.408	-3.584	.005	.002	3	1
UCEC	JNK_pT183_Y185 →	-0.242	-1.986	.001	.032	3	1
UCEC	Ku80 →	+0.221	+2.013	.038	.018	3	1
UCEC	MAPK_pT202_Y204 →	-0.467	-2.321	.027	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

eEF2 by REEP3 expression — UCEC

Explore this box plot interactively →