REEP2

Across TCGA pan-cancer cohorts, REEP2 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated REEP2 data layer compared with 4 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher REEP2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated REEP2 expression acts as an unfavorable survival marker, although some lineages such as BRCA and PAAD show a favorable association.

UVM, KIRC, and ACC are the cancer types where REEP2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	0.390	0.803	<.001	121	view →
KIRC	DFS	Tertile	All	0.740	0.857	<.001	73	view →
ACC	DFS	Median	All	0.403	0.735	<.001	54	view →
COAD	DFS	Tertile	II,III,IV	0.547	0.720	.001	53	view →
UCEC	DFS	Quartile	All	0.624	0.780	.002	52	view →
BRCA	OS	Quartile	III,IV	0.959	0.848	.005	50	view →
BLCA	DFS	Quartile	II,III,IV	0.302	0.535	.009	42	view →
MESO	OS	Median	III,IV	0.452	0.663	.002	41	view →
PAAD	DFS	Quartile	All	0.509	0.238	.001	34	view →
UCS	DFS	Tertile	IV	0.237	0.818	.024	24	view →
READ	OS	Median	III,IV	0.819	0.978	.007	19	view →
THCA	OS	Median	II,III,IV	0.971	0.332	.019	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

REEP2–UVM (DFS)

Open the UVM breakdown →