REEP2

Across TCGA pan-cancer cohorts, REEP2 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of REEP2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where REEP2 RNA is repressed in tumor relative to normal tissue. In most cancer types REEP2 is over-expressed in tumor, although a few such as KIRC and BLCA show the opposite, repressed pattern.

KIRC, LUAD, and BLCA are the cancer types where REEP2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in REEP2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	−0.702	<.001	12	view →
LUAD	All	III,IV	+0.851	<.001	11	view →
BLCA	Male	IV	−3.262	<.001	9	view →
COAD	Male	II,III,IV	−1.564	<.001	9	view →
THCA	All	II,III,IV	+0.798	<.001	9	view →
LIHC	Female	II,III,IV	+0.798	<.001	8	view →
LUSC	Female	All	+1.543	<.001	6	view →
BRCA	All	III,IV	−0.909	<.001	6	view →
STAD	All	All	−1.268	.003	4	view →
CHOL	All	All	+1.096	.004	3	view →
READ	All	All	−1.948	.001	2	view →
PRAD	All	All	−0.910	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

REEP2–KIRC

Open the KIRC breakdown →