RECQL5

Across TCGA cell cohorts, RECQL5 mutation is significantly associated with the RNA expression of many other genes, with 353 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RECQL5-associated genes across cancer lineages are PGRMC2, FAM47B, and SNX6. Each is linked with RECQL5 in more than 2 cancer types. Because this analysis shows association rather than direction, both RECQL5-to-partner and partner-to-RECQL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PGRMC2 grouped by RECQL5-low versus RECQL5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RECQL5→partner) and Y-score (partner→RECQL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PGRMC2 →	+0.537	+3.364	.008	.002	3	3
SOFT_TISSUE	FAM47B →	+0.004	+4.369	<.001	.008	3	2
LARGE_INTESTINE	SNX6 →	+0.713	+3.364	<.001	.002	3	2
LARGE_INTESTINE	EXOC6B →	+0.753	+3.364	.005	.002	3	2
LARGE_INTESTINE	PPP2R5E →	+0.548	+3.169	.002	.009	3	2
LARGE_INTESTINE	ZBTB21 →	+0.728	+3.451	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 353 associations by consensus.

PGRMC2 by RECQL5 expression — LARGE_INTESTINE

Explore this box plot interactively →