RECQL

Across TCGA patient cohorts, RECQL mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RECQL-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and FoxM1. Each is linked with RECQL in more than 1 cancer types. Because this analysis shows association rather than direction, both RECQL-to-partner and partner-to-RECQL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by RECQL-low versus RECQL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RECQL→partner) and Y-score (partner→RECQL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.516	+2.720	.020	.003	3	2
UCEC	EGFR_pY1068 →	-0.308	-2.000	.001	.009	3	1
UCEC	FoxM1 →	+0.201	+2.169	.038	.003	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.491	+1.765	.010	.014	3	1
UCEC	HSP70 →	-0.297	-2.575	.049	.010	3	1
UCEC	IGFBP2 →	-0.850	-1.807	<.001	.025	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Caspase-7-cleavedD198 by RECQL expression — UCEC

Explore this box plot interactively →