RECQL

Across TCGA cell cohorts, RECQL mutation is significantly associated with the drug of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RECQL-associated genes across cancer lineages are IGFR_3801, JAK1_8709, and VSP34_8731. Each is linked with RECQL in more than 1 cancer types. Because this analysis shows association rather than direction, both RECQL-to-partner and partner-to-RECQL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFR_3801 grouped by RECQL-low versus RECQL-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RECQL→partner) and Y-score (partner→RECQL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	IGFR_3801 →	-0.624	-2.743	.023	.046	3	1
LARGE_INTESTINE	JAK1_8709 →	+0.378	+2.871	.044	.021	3	1
LARGE_INTESTINE	VSP34_8731 →	+0.409	+2.710	.032	.027	3	1
LARGE_INTESTINE	GSK2110183B →	+0.635	+2.871	.027	.021	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

IGFR_3801 by RECQL expression — LARGE_INTESTINE

Explore this box plot interactively →