RECK

Across TCGA patient cohorts, RECK mutation is significantly associated with the RNA expression of many other genes, with 2,637 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RECK-associated genes across cancer lineages are RPL23AP82, RN7SL83P, and OR7K1P. Each is linked with RECK in more than 2 cancer types. Because this analysis shows association rather than direction, both RECK-to-partner and partner-to-RECK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL23AP82 grouped by RECK-low versus RECK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RECK→partner) and Y-score (partner→RECK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPL23AP82 →	+0.421	+1.958	<.001	<.001	3	3
UCEC	RN7SL83P →	+0.128	+2.035	<.001	.002	3	3
HNSC	OR7K1P →	+0.103	+5.912	<.001	.002	3	3
UCEC	JOSD1 →	+0.344	+1.473	.004	.007	3	3
HNSC	RNU6-275P →	+0.449	+5.736	<.001	.003	3	2
SKCM	RN7SL627P →	+0.039	+2.965	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,637 associations by consensus.

RPL23AP82 by RECK expression — UCEC

Explore this box plot interactively →