RECK

Across TCGA patient cohorts, RECK mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RECK-associated genes across cancer lineages are FASN, Caspase-7-cleavedD198, and C-Raf. Each is linked with RECK in more than 1 cancer types. Because this analysis shows association rather than direction, both RECK-to-partner and partner-to-RECK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by RECK-low versus RECK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RECK→partner) and Y-score (partner→RECK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.335	+1.807	.012	.025	3	2
UCEC	Caspase-7-cleavedD198 →	+0.991	+2.267	<.001	<.001	3	2
UCEC	C-Raf →	+0.230	+3.700	<.001	.001	3	2
UCEC	14-3-3_beta →	-0.084	-1.673	.014	.040	3	1
UCEC	EGFR_pY1068 →	-0.270	-3.700	.001	.001	3	1
UCEC	eIF4E →	+0.200	+3.598	.005	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

FASN by RECK expression — UCEC

Explore this box plot interactively →