RECK

Across TCGA cell cohorts, RECK RNA expression is significantly associated with the go_rna of many other GO terms, with 5,849 significant associations in total. BONE shows the largest number of these associations.

The most reproducible RECK-associated GO terms across cancer lineages are Regulation of establishment of blood-brain barrier, Positive regulation of stress fiber assembly, and Positive regulation of actin filament bundle assembly. Each is linked with RECK in more than 17 cancer types. Because this analysis shows association rather than direction, both RECK-to-partner and partner-to-RECK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of establishment of blood-brain barrier grouped by RECK-low versus RECK-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RECK→partner) and Y-score (partner→RECK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of establishment of blood-brain barrier →	+1.358	+3.195	<.001	<.001	3	18
BONE	Positive regulation of stress fiber assembly →	+0.179	+1.656	<.001	<.001	3	13
BONE	Positive regulation of actin filament bundle assembly →	+0.190	+1.637	<.001	<.001	3	13
SOFT_TISSUE	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.076	+0.712	.002	.006	2	13
BREAST	Cell division →	+0.090	+1.580	<.001	<.001	3	12
BONE	Regulation of mesenchymal stem cell proliferation →	+0.250	+1.830	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,849 associations by consensus.

Regulation of establishment of blood-brain barrier by RECK expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →