REC8

Across TCGA patient cohorts, REC8 mutation is significantly associated with the RNA expression of many other genes, with 1,369 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible REC8-associated genes across cancer lineages are RNU6-1085P, LINC02255, and DUSP15. Each is linked with REC8 in more than 2 cancer types. Because this analysis shows association rather than direction, both REC8-to-partner and partner-to-REC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1085P grouped by REC8-low versus REC8-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REC8→partner) and Y-score (partner→REC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-1085P →	+0.561	+5.435	<.001	.005	3	3
BRCA	LINC02255 →	+0.287	+5.307	<.001	<.001	3	2
UCEC	DUSP15 →	-0.702	-2.867	.004	.001	3	2
UCEC	BUB3 →	+0.453	+2.882	.001	.001	3	2
UCEC	OXA1L →	+0.344	+2.923	<.001	<.001	3	2
UCEC	C12orf43 →	+0.276	+3.839	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,369 associations by consensus.

RNU6-1085P by REC8 expression — HNSC

Explore this box plot interactively →