REC8

Across TCGA pan-cancer cohorts, REC8 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of REC8’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where REC8 RNA is repressed in tumor relative to normal tissue. In most cancer types REC8 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

KICH, KIRP, and KIRC are the cancer types where REC8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in REC8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−3.188	<.001	11	view →
KIRP	All	II,III,IV	−1.926	<.001	11	view →
KIRC	Male	II,III,IV	−1.745	<.001	11	view →
LUAD	Male	II,III,IV	−1.524	<.001	8	view →
UCEC	All	All	+1.625	<.001	6	view →
LUSC	Male	II,III,IV	−1.513	<.001	6	view →
COAD	All	II,III,IV	+0.467	.002	6	view →
THCA	All	All	+0.528	.002	4	view →
CHOL	All	All	+2.152	.001	2	view →
PRAD	All	All	−1.136	<.001	2	view →
STAD	All	IV	+2.500	.026	1	view →
LIHC	Male	All	−0.315	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

REC8–KICH

Open the KICH breakdown →