REC8

Across TCGA patient cohorts, REC8 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible REC8-associated genes across cancer lineages are PCNA, EGFR_pY1068, and eIF4E. Each is linked with REC8 in more than 1 cancer types. Because this analysis shows association rather than direction, both REC8-to-partner and partner-to-REC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by REC8-low versus REC8-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REC8→partner) and Y-score (partner→REC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PCNA →	+0.333	+2.815	.014	.036	3	2
UCEC	EGFR_pY1068 →	-0.253	-2.584	.012	.010	3	2
UCEC	eIF4E →	+0.222	+3.087	.008	<.001	3	2
UCEC	GATA6 →	-0.153	-2.985	.019	.034	3	2
UCEC	MEK1 →	+0.345	+2.000	.019	.030	3	2
UCEC	MSH6 →	-0.352	-3.169	.008	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

PCNA by REC8 expression — COAD

Explore this box plot interactively →