REC8

Across TCGA cell cohorts, REC8 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,099 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible REC8-associated GO terms across cancer lineages are Response to type I interferon, Protein linear polyubiquitination, and Regulation of viral life cycle. Each is linked with REC8 in more than 14 cancer types. Because this analysis shows association rather than direction, both REC8-to-partner and partner-to-REC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to type I interferon grouped by REC8-low versus REC8-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (REC8→partner) and Y-score (partner→REC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Response to type I interferon →	+0.129	+1.352	<.001	<.001	3	15
KIDNEY	Protein linear polyubiquitination →	+0.169	+1.582	<.001	<.001	3	13
LARGE_INTESTINE	Regulation of viral life cycle →	+0.125	+1.532	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	MDA-5 signaling pathway →	+0.290	+1.659	<.001	<.001	3	13
OESOPHAGUS	Post-transcriptional gene silencing →	+0.115	+1.789	.001	<.001	2	13
KIDNEY	Negative regulation of viral process →	+0.165	+1.458	.002	.009	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,099 associations by consensus.

Response to type I interferon by REC8 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →