REC8

Across TCGA cell cohorts, REC8 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible REC8-associated genes across cancer lineages are C6, SEMG2, and AMELX. Each is linked with REC8 in more than 1 cancer types. Because this analysis shows association rather than direction, both REC8-to-partner and partner-to-REC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C6 grouped by REC8-low versus REC8-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REC8→partner) and Y-score (partner→REC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C6 →	+0.201	+4.922	<.001	.009	3	1
LARGE_INTESTINE	SEMG2 →	+0.547	+4.363	<.001	<.001	3	1
LARGE_INTESTINE	AMELX →	+0.455	+3.440	.002	.006	3	1
LARGE_INTESTINE	S100G →	+1.026	+2.688	<.001	.008	3	1
LARGE_INTESTINE	CEACAM3 →	+0.541	+3.754	<.001	.002	3	1
LARGE_INTESTINE	OR10W1 →	+0.012	+3.240	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

C6 by REC8 expression — BLOOD_Leukemia

Explore this box plot interactively →