RDM1

Across TCGA patient cohorts, RDM1 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RDM1-associated genes across cancer lineages are EGFR_pY1068, MSH2, and Rab25. Each is linked with RDM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RDM1-to-partner and partner-to-RDM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by RDM1-low versus RDM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RDM1→partner) and Y-score (partner→RDM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.283	-3.169	.040	.020	3	1
UCEC	MSH2 →	-0.325	-3.160	.010	.019	3	1
UCEC	Rab25 →	-0.704	-3.169	<.001	.020	3	1
UCEC	PDCD4 →	-0.841	-3.169	.001	.020	2	1
UCEC	c-Kit →	-0.255	-3.169	.046	.020	2	1
UCEC	C-Raf →	+0.171	+3.169	.029	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

EGFR_pY1068 by RDM1 expression — UCEC

Explore this box plot interactively →