RDH12

Across TCGA patient cohorts, RDH12 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RDH12-associated genes across cancer lineages are EGFR_pY1068, FoxM1, and Ku80. Each is linked with RDH12 in more than 1 cancer types. Because this analysis shows association rather than direction, both RDH12-to-partner and partner-to-RDH12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by RDH12-low versus RDH12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RDH12→partner) and Y-score (partner→RDH12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.327	-3.459	.009	.005	3	1
UCEC	FoxM1 →	+0.271	+2.321	.037	.035	3	1
UCEC	Ku80 →	+0.337	+2.335	.004	.020	3	1
UCEC	Rab11 →	-0.167	-2.321	.022	.035	3	1
UCEC	Annexin-1 →	+0.790	+2.827	.002	.035	3	1
UCEC	Shc_pY317 →	-0.237	-2.321	.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

EGFR_pY1068 by RDH12 expression — UCEC

Explore this box plot interactively →