RCN1

Across TCGA patient cohorts, RCN1 mutation is significantly associated with the RNA expression of many other genes, with 1,128 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RCN1-associated genes across cancer lineages are PES1, PPM1F, and ESS2. Each is linked with RCN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RCN1-to-partner and partner-to-RCN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PES1 grouped by RCN1-low versus RCN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RCN1→partner) and Y-score (partner→RCN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PES1 →	+0.545	+2.807	.001	.003	3	1
UCEC	PPM1F →	+0.408	+2.617	<.001	<.001	3	1
UCEC	ESS2 →	+0.269	+2.098	.006	.003	3	1
UCEC	HIRA →	+0.387	+2.108	.008	.003	3	1
UCEC	SH3BP1 →	+0.624	+3.700	<.001	.001	3	1
UCEC	RTCB →	+0.544	+3.301	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,128 associations by consensus.

PES1 by RCN1 expression — UCEC

Explore this box plot interactively →