RCN1

Across TCGA patient cohorts, RCN1 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RCN1-associated genes across cancer lineages are 4E-BP1, Di-Ras3, and A-Raf_pS299. Each is linked with RCN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RCN1-to-partner and partner-to-RCN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by RCN1-low versus RCN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RCN1→partner) and Y-score (partner→RCN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.267	+3.169	.017	.018	3	2
UCEC	Di-Ras3 →	-0.166	-2.321	.006	.006	3	2
UCEC	A-Raf_pS299 →	-0.111	-2.321	.025	.034	3	1
UCEC	Heregulin →	-0.102	-2.986	.045	.035	3	1
UCEC	INPP4B →	-0.286	-2.459	.032	.019	3	1
UCEC	MEK1 →	+0.394	+1.807	.009	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

4E-BP1 by RCN1 expression — UCEC

Explore this box plot interactively →