RCL1

Across TCGA patient cohorts, RCL1 mutation is significantly associated with the RNA expression of many other genes, with 2,585 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RCL1-associated genes across cancer lineages are UBXN6, IFNWP9, and H3P40. Each is linked with RCL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RCL1-to-partner and partner-to-RCL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBXN6 grouped by RCL1-low versus RCL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RCL1→partner) and Y-score (partner→RCL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UBXN6 →	+0.465	+3.721	.002	<.001	3	2
LUSC	IFNWP9 →	+0.119	+5.625	<.001	.004	3	2
SKCM	H3P40 →	+0.086	+3.422	<.001	.006	3	2
UCEC	RBM12B-AS1 →	+0.585	+3.499	.002	.002	3	1
UCEC	EBLN3P →	+0.647	+3.475	.003	.002	3	1
UCEC	HNRNPA3P9 →	+0.333	+2.617	.004	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,585 associations by consensus.

UBXN6 by RCL1 expression — UCEC

Explore this box plot interactively →