RCE1

Across TCGA pan-cancer cohorts, RCE1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RCE1 data layer compared with 29 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RCE1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated RCE1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, LUAD, and LSCC are the cancer types where RCE1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.822	0.615	.007	31	view →
LUAD	OS	Median	II,III,IV	0.864	1.000	.018	12	view →
LSCC	OS	Median	All	0.833	0.959	.008	5	view →
CCRCC	DFS	Median	All	1.000	0.635	.021	2	view →
PDAC	OS	Quartile	All	0.833	0.921	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RCE1–HNSC (OS)

Open the HNSC breakdown →