RCC1

Across TCGA pan-cancer cohorts, RCC1 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated RCC1 data layer compared with 29 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher RCC1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RCC1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

CCRCC, LUAD, and PDAC are the cancer types where RCC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	III,IV	0.372	0.769	.006	27	view →
LUAD	OS	Median	III,IV	0.811	0.348	.002	23	view →
PDAC	OS	Quartile	III,IV	1.000	0.247	.008	16	view →
HNSC	DFS	Median	All	0.698	1.000	.020	12	view →
UCEC	DFS	Median	III,IV	0.904	0.295	.037	10	view →
OV	DFS	Tertile	All	1.000	0.805	.033	8	view →
LSCC	OS	Tertile	II,III,IV	0.889	0.616	.018	8	view →
COAD	DFS	Median	III,IV	1.000	0.841	.041	6	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

RCC1–CCRCC (DFS)

Open the CCRCC breakdown →