RC3H2

Across TCGA patient cohorts, RC3H2 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RC3H2-associated genes across cancer lineages are ACC1, 4E-BP1, and GAPDH. Each is linked with RC3H2 in more than 2 cancer types. Because this analysis shows association rather than direction, both RC3H2-to-partner and partner-to-RC3H2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by RC3H2-low versus RC3H2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RC3H2→partner) and Y-score (partner→RC3H2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC1 →	+0.297	+1.378	.006	.008	3	3
UCEC	4E-BP1 →	+0.366	+1.807	<.001	<.001	3	3
LUSC	GAPDH →	+0.823	+3.009	.017	.019	3	2
UCEC	Cyclin-B1 →	+0.634	+2.050	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.080	-2.295	.007	.005	3	2
UCEC	EGFR_pY1068 →	-0.289	-2.662	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

ACC1 by RC3H2 expression — UCEC

Explore this box plot interactively →