RC3H1-IT1

Across TCGA pan-cancer cohorts, RC3H1-IT1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated RC3H1-IT1 data layer.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher RC3H1-IT1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RC3H1-IT1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and LAML show a favorable association.

LUSC, KIRC, and UVM are the cancer types where RC3H1-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Tertile	III,IV	0.429	0.725	.001	34	view →
KIRC	DFS	Quartile	IV	0.204	0.642	.003	28	view →
UVM	OS	Tertile	III,IV	0.136	0.874	<.001	21	view →
BRCA	OS	Quartile	All	0.980	0.954	.009	21	view →
SKCM	DFS	Tertile	II,III,IV	0.087	0.325	.002	18	view →
MESO	OS	Tertile	IV	0.217	0.655	.016	18	view →
THCA	OS	Tertile	III,IV	0.285	0.957	.007	15	view →
UCEC	DFS	Median	All	0.617	0.652	.015	14	view →
LAML	DFS	Median	All	0.598	0.210	<.001	12	view →
TGCT	DFS	Tertile	III,IV	0.604	1.000	.044	12	view →
OV	OS	Tertile	IV	0.599	0.905	.004	10	view →
ACC	DFS	Tertile	All	0.396	0.646	.011	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

RC3H1-IT1–LUSC (DFS)

Open the LUSC breakdown →