RC3H1-IT1

Across TCGA pan-cancer cohorts, RC3H1-IT1 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of RC3H1-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in rectum adenocarcinoma (READ), where RC3H1-IT1 RNA is repressed in tumor relative to normal tissue. In most cancer types RC3H1-IT1 is over-expressed in tumor, although a few such as READ and KICH show the opposite, repressed pattern.

READ, KIRP, and KICH are the cancer types where RC3H1-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RC3H1-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
READ	Male	All	−0.170	.002	4	view →
KIRP	All	All	+0.054	.012	4	view →
KICH	Female	III,IV	−0.150	<.001	3	view →
LUSC	Male	II,III,IV	−0.115	.026	3	view →
COAD	Female	II,III,IV	+0.131	.043	1	view →
LUAD	All	III,IV	−0.082	.049	1	view →
LIHC	Female	All	+0.036	.023	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

RC3H1-IT1–READ

Open the READ breakdown →