RBX1

Across TCGA pan-cancer cohorts, RBX1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated RBX1 data layer compared with 22 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher RBX1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated RBX1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and GBM show a favorable association.

UCEC, CCRCC, and LSCC are the cancer types where RBX1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	II,III,IV	1.000	0.391	.007	24	view →
CCRCC	DFS	Quartile	All	0.534	0.861	<.001	18	view →
LSCC	OS	Tertile	III,IV	0.470	0.943	.010	9	view →
GBM	DFS	Tertile	All	0.868	0.666	.011	7	view →
LUAD	OS	Median	All	0.613	0.844	.048	2	view →
HNSC	OS	Quartile	II,III,IV	1.000	0.932	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

RBX1–UCEC (DFS)

Open the UCEC breakdown →