RBX1

Across TCGA pan-cancer cohorts, RBX1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RBX1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RBX1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RBX1 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRC, HNSC, and LIHC are the cancer types where RBX1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RBX1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	+0.368	<.001	11	view →
HNSC	All	III,IV	+0.406	<.001	10	view →
LIHC	Female	II,III,IV	+1.187	<.001	9	view →
KICH	Female	All	−0.900	<.001	7	view →
BRCA	All	III,IV	+0.502	<.001	6	view →
CHOL	Male	All	+2.085	<.001	5	view →
BLCA	All	All	+0.443	.005	5	view →
COAD	Female	All	+0.371	.005	4	view →
STAD	All	All	+0.278	.027	3	view →
ESCA	Male	All	+0.748	.003	2	view →
KIRP	All	IV	+0.487	.019	2	view →
UCEC	All	II,III,IV	+0.367	.038	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RBX1–KIRC

Open the KIRC breakdown →