RBSN

Across TCGA patient cohorts, RBSN mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBSN-associated genes across cancer lineages are PDCD4, ERK2, and JNK_pT183_Y185. Each is linked with RBSN in more than 1 cancer types. Because this analysis shows association rather than direction, both RBSN-to-partner and partner-to-RBSN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by RBSN-low versus RBSN-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBSN→partner) and Y-score (partner→RBSN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PDCD4 →	-0.450	-2.321	.024	.035	3	2
UCEC	ERK2 →	+0.141	+1.584	.028	.009	3	2
UCEC	JNK_pT183_Y185 →	-0.166	-2.415	.003	.003	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.398	-2.321	.008	.005	3	2
UCEC	PKC-delta_pS664 →	-0.084	-1.990	.037	.030	3	2
UCEC	Rad50 →	-0.181	-1.584	.025	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

PDCD4 by RBSN expression — SKCM

Explore this box plot interactively →