RBSN

Across TCGA pan-cancer cohorts, RBSN RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of RBSN’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where RBSN RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RBSN is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

LIHC, LUAD, and LUSC are the cancer types where RBSN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RBSN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+0.908	<.001	8	view →
LUAD	All	II,III,IV	−0.398	<.001	8	view →
LUSC	Female	II,III,IV	−1.040	<.001	7	view →
KICH	Female	All	−1.029	<.001	6	view →
THCA	All	II,III,IV	−0.427	.004	4	view →
BRCA	Female	All	−0.294	<.001	4	view →
CHOL	All	All	+0.984	<.001	3	view →
UCEC	All	All	−0.948	<.001	2	view →
KIRC	Male	II,III,IV	−0.255	.021	2	view →
BLCA	Male	IV	−0.919	.015	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

RBSN–LIHC

Open the LIHC breakdown →