RBPMS

Across TCGA patient cohorts, RBPMS mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBPMS-associated genes across cancer lineages are eEF2, eIF4G, and FOXO3a_pS318_S321. Each is linked with RBPMS in more than 1 cancer types. Because this analysis shows association rather than direction, both RBPMS-to-partner and partner-to-RBPMS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by RBPMS-low versus RBPMS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBPMS→partner) and Y-score (partner→RBPMS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.458	+2.321	.010	.035	3	1
UCEC	eIF4G →	+0.375	+2.321	.016	.035	3	1
UCEC	FOXO3a_pS318_S321 →	-0.166	-2.321	.008	.035	3	1
UCEC	GAPDH →	+0.648	+2.999	.016	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.212	-2.308	.012	.036	3	1
UCEC	Ku80 →	+0.257	+2.335	.030	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

eEF2 by RBPMS expression — UCEC

Explore this box plot interactively →