RBPJL

Across TCGA patient cohorts, RBPJL mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBPJL-associated genes across cancer lineages are MEK1, PAI-1, and SETD2. Each is linked with RBPJL in more than 1 cancer types. Because this analysis shows association rather than direction, both RBPJL-to-partner and partner-to-RBPJL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by RBPJL-low versus RBPJL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBPJL→partner) and Y-score (partner→RBPJL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.355	+1.906	.015	.016	3	2
COAD	PAI-1 →	+1.055	+2.815	.001	.036	3	1
COAD	SETD2 →	+0.698	+2.815	.001	.036	3	1
COAD	TAZ →	+0.221	+2.832	.040	.035	3	1
UCEC	14-3-3_beta →	-0.109	-3.432	.007	.005	3	1
UCEC	A-Raf_pS299 →	-0.140	-3.459	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

MEK1 by RBPJL expression — UCEC

Explore this box plot interactively →