RBPJL

Across TCGA cell cohorts, RBPJL mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RBPJL-associated genes across cancer lineages are RBMY1F, KRTAP29-1, and MBD3L5. Each is linked with RBPJL in more than 1 cancer types. Because this analysis shows association rather than direction, both RBPJL-to-partner and partner-to-RBPJL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBMY1F grouped by RBPJL-low versus RBPJL-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBPJL→partner) and Y-score (partner→RBPJL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RBMY1F →	+0.065	+5.022	<.001	.002	3	1
SKIN	KRTAP29-1 →	+0.025	+5.217	<.001	<.001	3	1
SKIN	MBD3L5 →	+0.021	+4.415	<.001	.007	3	1
SKIN	C7orf77 →	+0.079	+4.415	<.001	.007	3	1
CNS	TPD52L3 →	+0.103	+6.357	<.001	<.001	3	1
CNS	HELT →	+0.041	+5.321	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

RBMY1F by RBPJL expression — SKIN

Explore this box plot interactively →