RBP5

Across TCGA patient cohorts, RBP5 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBP5-associated genes across cancer lineages are FASN, FoxM1, and ACC1. Each is linked with RBP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both RBP5-to-partner and partner-to-RBP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by RBP5-low versus RBP5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBP5→partner) and Y-score (partner→RBP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.535	+3.000	.006	.036	3	1
UCEC	FoxM1 →	+0.304	+2.321	.019	.035	3	1
UCEC	ACC1 →	+0.451	+3.169	.013	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.282	-3.446	<.001	.005	3	1
UCEC	Myosin-IIa →	+0.188	+2.818	.044	.035	3	1
UCEC	Notch1 →	+0.255	+3.179	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

FASN by RBP5 expression — UCEC

Explore this box plot interactively →