RBP5

Across TCGA pan-cancer cohorts, RBP5 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of RBP5’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where RBP5 RNA is repressed in tumor relative to normal tissue. In most cancer types RBP5 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

KICH, KIRP, and KIRC are the cancer types where RBP5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RBP5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	II,III,IV	−5.183	<.001	11	view →
KIRP	All	II,III,IV	−3.376	<.001	10	view →
KIRC	All	II,III,IV	+1.260	<.001	10	view →
COAD	Female	II,III,IV	−0.779	<.001	8	view →
LIHC	Female	All	−1.642	<.001	7	view →
THCA	Female	All	−0.842	<.001	6	view →
CHOL	All	All	−3.885	<.001	5	view →
UCEC	All	All	−1.405	<.001	4	view →
LUSC	Male	II,III,IV	−1.146	<.001	4	view →
HNSC	Female	II,III,IV	+0.769	.020	4	view →
ESCA	All	II,III,IV	+1.089	.005	3	view →
BRCA	All	IV	+0.675	.018	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

RBP5–KICH

Open the KICH breakdown →