RBP1

Across TCGA patient cohorts, RBP1 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBP1-associated genes across cancer lineages are 14-3-3_beta, ERK2, and FOXO3a_pS318_S321. Each is linked with RBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RBP1-to-partner and partner-to-RBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by RBP1-low versus RBP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBP1→partner) and Y-score (partner→RBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.105	-2.308	.037	.036	3	1
UCEC	ERK2 →	+0.303	+2.321	.001	.035	3	1
UCEC	FOXO3a_pS318_S321 →	-0.155	-2.321	.013	.035	3	1
UCEC	Heregulin →	-0.190	-3.459	.002	.005	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.635	+2.321	.012	.035	3	1
UCEC	INPP4B →	-0.371	-2.999	.022	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

14-3-3_beta by RBP1 expression — UCEC

Explore this box plot interactively →