RBP1

Across TCGA pan-cancer cohorts, RBP1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of RBP1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RBP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RBP1 is over-expressed in tumor, although a few such as KIRP and KIRC show the opposite, repressed pattern.

HNSC, KIRP, and KIRC are the cancer types where RBP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RBP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+3.076	<.001	12	view →
KIRP	Male	All	−1.002	<.001	7	view →
KIRC	Male	II,III,IV	−0.881	<.001	6	view →
LUSC	All	All	+1.551	<.001	5	view →
BLCA	Female	III,IV	−1.728	<.001	4	view →
COAD	Female	All	+1.392	.002	4	view →
LUAD	All	All	−0.521	.001	3	view →
CHOL	Male	All	+1.735	<.001	2	view →
PRAD	All	All	−1.619	<.001	2	view →
KICH	Male	II,III,IV	−1.461	.011	2	view →
UCEC	All	II,III,IV	−1.173	.038	2	view →
LIHC	All	All	−0.928	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

RBP1–HNSC

Open the HNSC breakdown →