RBM5-AS1

Across TCGA pan-cancer cohorts, RBM5-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated RBM5-AS1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RBM5-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated RBM5-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

HNSC, BRCA, and THCA are the cancer types where RBM5-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.405	0.255	<.001	105	view →
BRCA	DFS	Median	III,IV	0.934	0.818	.001	48	view →
THCA	DFS	Median	All	0.861	0.953	.001	45	view →
ACC	DFS	Tertile	IV	0.096	0.632	.001	40	view →
COAD	DFS	Tertile	II,III,IV	0.786	0.499	.002	28	view →
UCS	DFS	Tertile	IV	0.956	0.422	.024	24	view →
STAD	OS	Tertile	III,IV	0.615	0.287	.006	21	view →
READ	OS	Median	II,III,IV	0.959	0.300	.001	18	view →
UVM	DFS	Tertile	III,IV	0.377	0.837	.003	12	view →
BLCA	OS	Median	All	0.213	0.591	.002	12	view →
LGG	OS	Tertile	All	0.736	0.903	.006	11	view →
UCEC	OS	Median	All	0.562	0.762	.014	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

RBM5-AS1–HNSC (DFS)

Open the HNSC breakdown →