RBM3

Across TCGA patient cohorts, RBM3 mutation is significantly associated with the RNA expression of many other genes, with 761 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBM3-associated genes across cancer lineages are RN7SL248P, CPSF7, and CHEK1. Each is linked with RBM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RBM3-to-partner and partner-to-RBM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by RBM3-low versus RBM3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBM3→partner) and Y-score (partner→RBM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL248P →	+0.075	+3.500	<.001	.002	3	2
UCEC	CPSF7 →	+0.420	+3.475	.002	.002	3	1
UCEC	CHEK1 →	+0.600	+2.243	.007	.006	3	1
UCEC	PRSS53 →	+0.379	+3.538	<.001	.002	3	1
UCEC	SLC25A4 →	+0.488	+2.233	.009	.006	3	1
UCEC	AP1S3 →	+0.678	+2.276	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 761 associations by consensus.

RN7SL248P by RBM3 expression — UCEC

Explore this box plot interactively →