RBM23

Across TCGA patient cohorts, RBM23 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBM23-associated genes across cancer lineages are HER2_pY1248, C-Raf_pS338, and FOXO3a_pS318_S321. Each is linked with RBM23 in more than 1 cancer types. Because this analysis shows association rather than direction, both RBM23-to-partner and partner-to-RBM23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HER2_pY1248 grouped by RBM23-low versus RBM23-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBM23→partner) and Y-score (partner→RBM23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	HER2_pY1248 →	-0.168	-3.000	.044	.036	3	2
SKCM	C-Raf_pS338 →	-0.144	-3.000	.045	.036	3	1
UCEC	FOXO3a_pS318_S321 →	-0.131	-3.321	.013	.009	3	1
UCEC	Ku80 →	+0.240	+1.713	.016	.027	3	1
UCEC	Lck →	+0.211	+1.700	.013	.044	3	1
UCEC	MAPK_pT202_Y204 →	-0.408	-2.321	.041	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

HER2_pY1248 by RBM23 expression — SKCM

Explore this box plot interactively →